Premature Aging
TPPTM Antioxidant is formulated to control free radicals that affect hydrophilic and hydrophobic moieties of various molecules. Oxidized molecules lose their functionality and create a free radical ""domino effect"" in the system. This natural formulation incorporates specific antioxidant molecules that scavenge and correct radical damaged molecules. These molecules include proteins, lipids and other oxidized molecules found in the cytosol, extracellular environment and lipophilic structures. Most metabolic disorders and degenerative diseases have some root in excess free radical damage of cells and vital membranes. TPPTM Antioxidant is designed to serve as both a preventative as well as a corrective product. Its benefits include control of oxidized and glycated molecules, improvement of cellular vitality and control of the aging process."
Scavenger of Oxidized and Damaged Proteins
Oxidative reactions generate free radical damage to various molecules including proteins. Free radicals have been implicated in accelerating the aging process as well as several diseases, including diabetes, arteriosclerosis, and neurodegenerative conditions. Under proper conditions of nutrition and adequate activity of antioxidant enzymes, the free radical damage is minimized. However, in many instances, the body is overwhelmed by the load of pro-oxidants (free radical generating molecules), resulting in oxidative stress conditions.
One of the consequences of oxidative stress is the formation of oxidized proteins. Oxidized proteins often loose their function (become inactive), and undergo unfolding or conformational change of their structure which enhances their susceptibility to proteolysis. For instance, oxidized proteins in blood or extracellular fluid, include hormones, immune system proteins, transport proteins, and other proteins needed at various cellular locations.
As these oxidized proteins loose their biological function, they may not carry out the cellular tasks and biochemical reactions they are meant to perform. For instance, an oxidized hormone may not be able to attach to its receptor on the cell surface; an oxidized enzyme may not perform its activity; an oxidized antibody molecule will not bind to its antigen.
Oxidative reactions occur in a cascade manner. Therefore, oxidation of one protein may lead to further oxidation reactions within the same molecule and/or other molecules, which amplify the damaging effect. Thus, any oxidation of a protein if not corrected may result in impairment of biochemical functions of vital importance to the cellular viability. In order to avoid the cascade effect, oxidized proteins may be reduced by an antioxidant or removed by proteolysis. Several studies have indicated that oral proteases bound to the a2-macroglobulin hydrolyze immune complexes, proteinaceous debris, damaged proteins, and acute phase plasma proteins in the blood stream. It is suggested that oral proteases may help hydrolyze and remove extracellular proteins damaged by free radicals which are especially susceptible to proteolysis, as mentioned above.
INDICATIONS:
CELLULAR DAMAGE
Cellular membranes are composed of proteins and lipids, principally phospholipids and cholesterol, in the form of a lipid bilayer. For the cellular membrane to support all its necessary functions it must have a well defined "fluidity". This fluidity, in turn, depends upon the appropriate degree of unsaturation in the fatty acids of the phospholipids. These unsaturated fatty acids are susceptible to oxidative attack, and therefore must be defended by cellular antioxidants.
PREMATURE AGING
The signs and symptoms of aging appear at an accelerated pace in individuals exposed to a highly oxidative environment. This is most clearly seen when the symptoms are externally visible, as in the premature aging of the skin when it is overexposed to an oxidative environment (such as excess sunlight).
COMPONENT BENEFITS:
TzymeTM is the trademark of a proprietary blend of highly active, functional enzymes. These enzymes are pH balanced and GI tract stable. This blend is formulated to enhance the digestive process and impart systemic benefits.
TzymeTM Protease Blend - This proprietary blend of highly active proteolytic enzymes has a wide range of pH stability. Proteolytic enzymes taken orally under certain conditions have been shown to be absorbed in substantial quantities into the blood. Once in the blood circulation, the enzymes in this blend bind to serum proteins, especially alpha 2-macroglobulin (a2M), and impart immunomodulatory benefits. One of the best-established functions served by the oral proteases in TzymeTM blend is in the maintenance of normal blood flow. This is accomplished by breaking down blood clots (fibrinolysis) and platelet aggregation within blood vessels and breaking down excess extra-vascular plasma proteins as in edema. In addition to these benefits, the proteases in TzymeTM blends help to hydrolyze oxidized proteins, thus eliminating the free radical damage process.
TzymeTM AntiOx Blend - The highly active antioxidants in this blend ensure the reduction of oxidized molecules in the system. The reducing enzymes in this formulation include catalase, glutathione, SOD, as well as various sources of bioflavonoids, vitamin C, carotenoids, lipoic acid and other potent antioxidants. The specific ingredients in this blend can help prevent and correct free radicals within the aqueous and lipophilic environments."
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